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Issue 17, 2016
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Comparison of metal free polymer–dye conjugation strategies in protic solvents

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Abstract

Polymer–dye conjugations are one of the common examples for polymer modifications. They represent a crucial step for imaging in optical microscopy or for tracing and marking macromolecules. In this work, we present a comparison between quick and efficient conjugation reactions that do not rely on the use of a metal catalyst, which could contaminate the resulting polymer and hinder its use for subsequent biological applications. Moreover, since the conjugation strategy needs to be compatible with the solvent system used to solubilise the polymer, we focussed our attention on assessing these conjugation approaches for their feasibility with a sample polymer that is only soluble in protic solvents. The methods studied include the ring-strain promoted azide–alkyne click reaction, thiol/maleimide conjugation as well as the 1,2,4-triazoline-3,5-dione (TAD) with a diene moiety, one of the latest click chemistries available.

Graphical abstract: Comparison of metal free polymer–dye conjugation strategies in protic solvents

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Publication details

The article was received on 22 Mar 2016, accepted on 05 Apr 2016 and first published on 07 Apr 2016


Article type: Paper
DOI: 10.1039/C6PY00518G
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Citation: Polym. Chem., 2016,7, 3046-3055

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    Comparison of metal free polymer–dye conjugation strategies in protic solvents

    J. Gaitzsch, M. Delahaye, A. Poma, F. Du Prez and G. Battaglia, Polym. Chem., 2016, 7, 3046
    DOI: 10.1039/C6PY00518G

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