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Issue 15, 2016
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Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

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Abstract

Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance.

Graphical abstract: Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

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Publication details

The article was received on 26 Jan 2016, accepted on 13 Mar 2016 and first published on 16 Mar 2016


Article type: Paper
DOI: 10.1039/C6PY00146G
Citation: Polym. Chem., 2016,7, 2684-2690
  • Open access: Creative Commons BY license
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    Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

    I. Insua, E. Liamas, Z. Zhang, A. F. A. Peacock, A. M. Krachler and F. Fernandez-Trillo, Polym. Chem., 2016, 7, 2684
    DOI: 10.1039/C6PY00146G

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