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Issue 14, 2016
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A dendronized heparin–gadolinium polymer self-assembled into a nanoscale system as a potential magnetic resonance imaging contrast agent

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Abstract

We reported the preparation and characterization of a dendronized heparin–gadolinium polymer (Dendronized-heparin–Gd) based nanoscale system as a potential MRI contrast agent, which combined the advantages of heparin and the peptide dendron. The dendronized polymer self-assembled into a compact nanoscale system, which was confirmed by dynamic light scattering (DLS) and scanning electron microscopy (SEM) results, and a negative charge was observed. The content of gadolinium (Gd(III)) was 6% as a weight percentage, determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis. The in vitro and in vivo toxicity studies demonstrated that the Dendronized-heparin–Gd polymeric nanoscale system exhibited good biocompatibility – no obvious side effects to normal cells and organs of healthy mice were observed by a cytotoxicity assay, body weight shift and histological analysis. The polymeric nanoscale system showed a 7-fold increase in the T1 relaxivity compared to the clinical agent Magnevist (Gd-DTPA). In vivo MR imaging studies on the mice bearing 4T1 breast tumors showed that the nanoscale system had a much higher contrast enhancement in the tumor than Gd-DTPA. The distribution of Gd(III) in the tissues at different times after administration indicated a higher Gd(III) accumulation in the tumor for the nanoscale system compared to Gd-DTPA. Overall, the dendronized heparin polymer based nanoscale system with a high contrast enhancement in tumors and low side effects may be used as a MRI contrast agent for disease diagnosis.

Graphical abstract: A dendronized heparin–gadolinium polymer self-assembled into a nanoscale system as a potential magnetic resonance imaging contrast agent

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Article information


Submitted
12 Jan 2016
Accepted
17 Feb 2016
First published
29 Feb 2016

Polym. Chem., 2016,7, 2531-2541
Article type
Paper

A dendronized heparin–gadolinium polymer self-assembled into a nanoscale system as a potential magnetic resonance imaging contrast agent

C. Guo, L. Sun, W. She, N. Li, L. Jiang, K. Luo, Q. Gong and Z. Gu, Polym. Chem., 2016, 7, 2531
DOI: 10.1039/C6PY00059B

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