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Issue 27, 2016
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Pd-catalyzed one-pot sequential unsymmetrical cross-coupling reactions of aryl/heteroaryl 1,2-dihalides

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Abstract

Efficient, step-economic, Pd(II)-catalyzed one-pot sequential Sonogashira/Sonogashira, Sonogashira/Suzuki, Sonogashira/Heck, Suzuki/Sonogashira, Suzuki/Suzuki, Suzuki/Heck, Heck/Sonogashira, Heck/Suzuki and Heck/Heck cross coupling reactions of sterically hindered aryl/heteroaryl 1,2-dihalides have been developed. The present methodology allows the conversion of easily available aryl/heteroaryl 1,2-dihalides into synthetically useful unsymmetrically substituted arenes/heteroarenes in good to excellent yields under mild reaction conditions. This methodology is a powerful tool for building a versatile substrate which can be utilized for the synthesis of various organic scaffolds.

Graphical abstract: Pd-catalyzed one-pot sequential unsymmetrical cross-coupling reactions of aryl/heteroaryl 1,2-dihalides

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Article information


Submitted
13 May 2016
Accepted
03 Jun 2016
First published
03 Jun 2016

Org. Biomol. Chem., 2016,14, 6487-6496
Article type
Paper

Pd-catalyzed one-pot sequential unsymmetrical cross-coupling reactions of aryl/heteroaryl 1,2-dihalides

A. K. Danodia, R. K. Saunthwal, M. Patel, R. K. Tiwari and A. K. Verma, Org. Biomol. Chem., 2016, 14, 6487
DOI: 10.1039/C6OB01049K

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