Dual-affinity peptide mediated inter-protein recognition

Hongyang Duan; Ling Zhu; Jingfei Hou; Jiaxi Peng; Hanyi Xie; Yuchen Lin; Changliang Liu; Wenzhe Li; Haiyan Xu; Chen Wang; Yanlian Yang

doi:10.1039/C6OB02292H

Dual-affinity peptide mediated inter-protein recognition†

Hongyang Duan,^ab Ling Zhu,^a Jingfei Hou,

^a Jiaxi Peng,^a Hanyi Xie,^ab Yuchen Lin,^a Changliang Liu,^a Wenzhe Li,^ab Haiyan Xu,*^c Chen Wang*^a and Yanlian Yang*^a

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* Corresponding authors

^a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
E-mail: wangch@nanoctr.cn, yangyl@nanoctr.cn
Tel: +86-10-82545561

^b Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

^c Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
E-mail: xuhy@pumc.edu.cn
Tel: +86-10-69156437

Abstract

We present for the first time an enhanced interaction affinity between an abundant soluble protein (human serum albumin) and a membrane protein (chemokine receptor 4) mediated by a dual-affinity peptide E5.

Organic & Biomolecular Chemistry

Dual-affinity peptide mediated inter-protein recognition†

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Dual-affinity peptide mediated inter-protein recognition

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