Issue 47, 2016

Phenyliodonium diacetate mediated carbotrifluoromethylation of N-acylhydrazones

Abstract

A concise, efficient and direct trifluoromethylation method of aldehyde-derived N-acylhydrazones has been firstly developed by using the combination of inexpensive, stable and commercially available TMSCF3 and PhI(OAc)2 as the CF3 source under mild reaction conditions. This method provides easy access to highly functionalized trifluoromethylated N-acylhydrazones, which could be used as trifluoromethyl synthetic building blocks to be further transformed into other valuable trifluoromethyl compounds.

Graphical abstract: Phenyliodonium diacetate mediated carbotrifluoromethylation of N-acylhydrazones

Supplementary files

Article information

Article type
Paper
Submitted
18 Sep 2016
Accepted
30 Oct 2016
First published
01 Nov 2016

Org. Biomol. Chem., 2016,14, 11162-11175

Phenyliodonium diacetate mediated carbotrifluoromethylation of N-acylhydrazones

W. Zhang, Y. Su, S. Chong, L. Wu, G. Cao, D. Huang, K. Wang and Y. Hu, Org. Biomol. Chem., 2016, 14, 11162 DOI: 10.1039/C6OB02041K

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