Copper-catalyzed intermolecular chloroazidation of α,β-unsaturated amides

Abstract

A highly practical copper-catalyzed intermolecular chloroazidation of α,β-unsaturated amides has been described, giving a series of azidochlorides in good-to-excellent yields. The stable azidoiodine(III) reagent and SOCl₂ were used as azide and chlorine sources, respectively. The synthetic applications of this protocol were also explored by a variety of synthetically useful transformations.