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Issue 29, 2016
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The xanthate route to organofluorine derivatives. A brief account

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Abstract

The present account summarises routes to organofluorine derivatives based on the chemistry of xanthates developed in the author's laboratory. It concerns mostly radical pathways, but a few ionic transformations are also discussed. The degenerative reversible transfer of xanthates allows radical addition even to unactivated alkenes and tolerates numerous functional groups, in particular common polar groups such as ketones, esters, amides, carbamates, nitriles etc. Since the fluorine atoms can be placed on the alkene or the xanthate partner or on both, this opens a convergent approach to a vast array of otherwise inaccessible organofluorine structures that could be of interest to the pharmaceutical and agrochemical industries and to materials science.

Graphical abstract: The xanthate route to organofluorine derivatives. A brief account

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Publication details

The article was received on 18 May 2016, accepted on 14 Jun 2016 and first published on 14 Jun 2016


Article type: Review Article
DOI: 10.1039/C6OB01087C
Org. Biomol. Chem., 2016,14, 6891-6912

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    The xanthate route to organofluorine derivatives. A brief account

    S. Z. Zard, Org. Biomol. Chem., 2016, 14, 6891
    DOI: 10.1039/C6OB01087C

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