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Issue 30, 2016
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Iodine-catalysed regioselective thiolation of flavonoids using sulfonyl hydrazides as sulfenylation reagents

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Abstract

Iodine-catalysed regioselective sulfenylation of flavonoid derivatives with sulfonyl hydrazides was developed. Various flavonoid thioethers were obtained in moderate to good yield. The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.

Graphical abstract: Iodine-catalysed regioselective thiolation of flavonoids using sulfonyl hydrazides as sulfenylation reagents

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Publication details

The article was received on 09 May 2016, accepted on 02 Jul 2016 and first published on 11 Jul 2016


Article type: Paper
DOI: 10.1039/C6OB01006G
Org. Biomol. Chem., 2016,14, 7304-7312

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    Iodine-catalysed regioselective thiolation of flavonoids using sulfonyl hydrazides as sulfenylation reagents

    X. Zhao, Z. Deng, A. Wei, B. Li and K. Lu, Org. Biomol. Chem., 2016, 14, 7304
    DOI: 10.1039/C6OB01006G

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