Jump to main content
Jump to site search

Issue 26, 2016
Previous Article Next Article

Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G

Author affiliations

Abstract

The cyclohexapeptide natural product dianthin G promotes osteoblast (bone-forming cell) proliferation in vitro at nanomolar concentrations, and is therefore considered a promising candidate for the treatment of osteoporosis. An Nα-methyl amide bond scan of dianthin G was performed to probe the effect of modifying amide bonds on osteoblast proliferation. In addition, to provide greater structural diversity, a series of dicarba dianthin G analogues was synthesised using ring closing metathesis. Dianthin G and one novel dicarba analogue increased the number of human osteoblasts and importantly they did not increase osteoclast (bone-resorbing cell) differentiation in bone marrow cells.

Graphical abstract: Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G

Back to tab navigation

Supplementary files

Article information


Submitted
06 May 2016
Accepted
25 May 2016
First published
27 May 2016

Org. Biomol. Chem., 2016,14, 6231-6243
Article type
Paper

Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G

Z. Amso, R. Kowalczyk, Y. Park, M. Watson, J. Lin, D. S. Musson, J. Cornish and M. A. Brimble, Org. Biomol. Chem., 2016, 14, 6231
DOI: 10.1039/C6OB00983B

Social activity

Search articles by author

Spotlight

Advertisements