Issue 26, 2016

Rh(iii)-catalyzed C–H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines

Abstract

A Rh(III)-catalyzed C–H activation/cyclization of oximes and alkenes for facile and regioselective access to isoquinolines has been developed. This protocol features mild reaction conditions and easily accessible starting materials, and has been applied to the concise synthesis of moxaverine. A kinetic isotope effect study was conducted and a plausible mechanism was proposed.

Graphical abstract: Rh(iii)-catalyzed C–H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
30 Apr 2016
Accepted
01 Jun 2016
First published
01 Jun 2016

Org. Biomol. Chem., 2016,14, 6201-6204

Author version available

Rh(III)-catalyzed C–H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines

R. Chen, J. Qi, Z. Mao and S. Cui, Org. Biomol. Chem., 2016, 14, 6201 DOI: 10.1039/C6OB00942E

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