A unique copper-catalyzed binucleophilic switching of 2-aminopyridine has been developed for the regioselective synthesis of 2- and 3-iodoimidazo[1,2-a]pyridines using alkenes/alkynes as coupling partners in the presence of molecular iodine under aerobic reaction conditions. This method was also applied to the synthesis of 2-iodo-3-phenylbenzo[d]imidazo[2,1-b]thiazoles. This protocol offers an easy route towards the synthesis of 2,3-diarylimidazo[1,2-a]pyridines.
![Graphical abstract: Switching the regioselectivity in the copper-catalyzed synthesis of iodoimidazo[1,2-a]pyridines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6OB00656F&imageInfo.ImageIdentifier.Year=2016)
S. Samanta, S. Jana, S. Mondal, K. Monir, S. K. Chandra and A. Hajra, Org. Biomol. Chem., 2016, 14, 5073 DOI: 10.1039/C6OB00656F
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