Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 17, 2016
Previous Article Next Article

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans

Author affiliations

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

Graphical abstract: Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans

Back to tab navigation

Associated articles

Supplementary files

Article information


Submitted
17 Mar 2016
Accepted
01 Apr 2016
First published
04 Apr 2016

Org. Biomol. Chem., 2016,14, 4027-4031
Article type
Communication

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans

A. D. Calderon, Y. Liu, X. Li, X. Wang, X. Chen, L. Li and P. G. Wang, Org. Biomol. Chem., 2016, 14, 4027
DOI: 10.1039/C6OB00586A

Social activity

Search articles by author

Spotlight

Advertisements