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Issue 16, 2016
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Catalytic alcoholysis of epoxides using metal-free cucurbituril-based solids

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Abstract

Metal-free cucurbit[7]uril (CB7) solid-state assemblies promote acid-catalysed alcoholysis of aliphatic and aromatic epoxides under mild conditions to give β-alkoxy alcohols, which are important intermediates for the synthesis of a vast range of compounds such as bioactive pharmaceuticals. The catalytic process is heterogeneous and the catalyst can be reused in consecutive runs without any reactivation treatment. The acid species responsible for the catalytic activity of CB7 may be entrapped hydronium ions.

Graphical abstract: Catalytic alcoholysis of epoxides using metal-free cucurbituril-based solids

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Publication details

The article was received on 07 Mar 2016, accepted on 22 Mar 2016 and first published on 01 Apr 2016


Article type: Communication
DOI: 10.1039/C6OB00512H
Org. Biomol. Chem., 2016,14, 3873-3877

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    Catalytic alcoholysis of epoxides using metal-free cucurbituril-based solids

    S. M. Bruno, A. C. Gomes, T. S. M. Oliveira, M. M. Antunes, A. D. Lopes, A. A. Valente, I. S. Gonçalves and M. Pillinger, Org. Biomol. Chem., 2016, 14, 3873
    DOI: 10.1039/C6OB00512H

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