Issue 10, 2016
From the journal:

Organic & Biomolecular Chemistry

Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides†

Andrew Edwardsa  and  Michael Rubin*ab  

* Corresponding authors

a Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA
E-mail: mrubin@ku.edu
Fax: +1 (785) 864-5396
Tel: +1 (785) 864-5071

b Department of Chemistry, North Caucasus State University, 1a Pushkin St., Stavropol 355009, Russian Federation

Abstract

An expeditious and cost-efficient method for synthesis of 1-arylcycloprop-2-ene-1-carboxamides was developed. This one-pot protocol involving coupling of amines with acyl chlorides, generated upon treatment of cyclopenylcarboxylic acids with oxalyl chloride, is applicable for the preparation of sensitive products with a reactive, unsubstituted strained double bond.

Graphical abstract: Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides

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Article information

DOI
https://doi.org/10.1039/C6OB00156D
Article type
Paper
Submitted
18 Jan 2016
Accepted
05 Feb 2016
First published
05 Feb 2016

Org. Biomol. Chem., 2016,14, 2883-2890

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Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides

A. Edwards and M. Rubin, Org. Biomol. Chem., 2016, 14, 2883 DOI: 10.1039/C6OB00156D

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