Issue 7, 2016
From the journal:

Organic & Biomolecular Chemistry

The first catalytic asymmetric thioacetalization by chiral phosphoric acid catalysis†

Jin-Sheng Yu,a   Wen-Biao Wua  and  Feng Zhou*bc  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062, China

b School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
E-mail: fzhou@chem.ecnu.edu.cn

c Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University, Shanghai, 200062, China

Abstract

We report here the first catalytic asymmetric thioacetalization of salicylaldehyde and dithiol. Chiral phosphoric acid STRIP C5 is identified as a powerful catalyst for this reaction to afford various chiral dithioacetals in high to excellent yields and enantioselectivities under mild conditions.

Graphical abstract: The first catalytic asymmetric thioacetalization by chiral phosphoric acid catalysis

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Article information

DOI
https://doi.org/10.1039/C5OB02495A
Article type
Communication
Submitted
07 Dec 2015
Accepted
15 Jan 2016
First published
15 Jan 2016

Org. Biomol. Chem., 2016,14, 2205-2209

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The first catalytic asymmetric thioacetalization by chiral phosphoric acid catalysis

J. Yu, W. Wu and F. Zhou, Org. Biomol. Chem., 2016, 14, 2205 DOI: 10.1039/C5OB02495A

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