Issue 1, 2016

Flexible synthesis of polyfunctionalised 3-fluoropyrroles


An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes. The methodology is concise, efficient and allows for the modular and systematic assembly of polysubstituted 3-fluoropyrroles. This synthesis provides an alternative and highly convergent strategy for the generation of these chemically and biologically important units.

Graphical abstract: Flexible synthesis of polyfunctionalised 3-fluoropyrroles

Supplementary files

Article information

Article type
19 Oct 2015
05 Nov 2015
First published
05 Nov 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 183-190

Author version available

Flexible synthesis of polyfunctionalised 3-fluoropyrroles

T. J. Cogswell, C. S. Donald and R. Marquez, Org. Biomol. Chem., 2016, 14, 183 DOI: 10.1039/C5OB02155C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity