(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.
R. R. Anugu, P. S. Mainkar, B. Sridhar and S. Chandrasekhar, Org. Biomol. Chem., 2016, 14, 1332 DOI: 10.1039/C5OB02047F
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