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Issue 4, 2016
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The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine

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Abstract

(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.

Graphical abstract: The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine

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Article information


Submitted
01 Oct 2015
Accepted
27 Nov 2015
First published
27 Nov 2015

Org. Biomol. Chem., 2016,14, 1332-1337
Article type
Paper
Author version available

The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine

R. R. Anugu, P. S. Mainkar, B. Sridhar and S. Chandrasekhar, Org. Biomol. Chem., 2016, 14, 1332
DOI: 10.1039/C5OB02047F

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