A regio- and stereoselective synthesis of highly substituted α-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products α-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.
L. Chen, L. Yu, Y. Deng, Y. Cui, G. Bian and J. Cao, Org. Biomol. Chem., 2016, 14, 564 DOI: 10.1039/C5OB01950H
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