Issue 2, 2016

Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides

Abstract

A regio- and stereoselective synthesis of highly substituted α-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products α-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.

Graphical abstract: Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides

Supplementary files

Article information

Article type
Paper
Submitted
19 Sep 2015
Accepted
19 Oct 2015
First published
21 Oct 2015

Org. Biomol. Chem., 2016,14, 564-569

Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides

L. Chen, L. Yu, Y. Deng, Y. Cui, G. Bian and J. Cao, Org. Biomol. Chem., 2016, 14, 564 DOI: 10.1039/C5OB01950H

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