Issue 45, 2016
From the journal:

Nanoscale

Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers†

Xiaohong Chen,a   Ying-Kun Qiu,a   Cally Owh,b   Xian Jun Loh*bcd  and  Yun-Long Wu*a  

* Corresponding authors

a Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, P. R. China
E-mail: wuyl@xmu.edu.cn

b Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore
E-mail: lohxj@imre.a-star.edu.sg

c Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore

d Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore

Abstract

A tumor active targeting β-cyclodextrin based nanocarrier β-NC-OEI-SS-FA was designed by the modification of star shaped cationic derivatives β-NC-OEI with folic acid through a disulfide bond, to co-deliver chemotherapeutic paclitaxel and the Nur77 gene for overcoming Bcl-2 mediated non-pump resistance by an “enemy to friend” strategy for potential drug resistant cancer therapy.

Graphical abstract: Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers

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Article information

DOI
https://doi.org/10.1039/C6NR08055C
Article type
Communication
Submitted
14 Oct 2016
Accepted
21 Oct 2016
First published
25 Oct 2016

Nanoscale, 2016,8, 18876-18881

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Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers

X. Chen, Y. Qiu, C. Owh, X. J. Loh and Y. Wu, Nanoscale, 2016, 8, 18876 DOI: 10.1039/C6NR08055C

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