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Issue 7, 2016
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A facile route to core–shell nanoparticulate formation of arsenic trioxide for effective solid tumor treatment

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Abstract

Arsenic trioxide has achieved great clinical success in the treatment of acute promyelocytic leukemia (APL). However, it is difficult to replicate the success in other cancers, such as solid tumors, in part because of the rapid renal clearance and dose-limiting toxicity. Nanotechnology is expected to overcome these disadvantages through altering its pharmacokinetics and concentrating the drug at the desired sites. Herein, we report a “one-pot” method to develop arsenic-based nanodrugs by in situ coating the as-prepared arsenic nanocomplexes with porous silica shells. This process can be easily reproduced and scaled up because no complicated synthesis and purification steps are involved. This core–shell embedding method endows nanodrugs with high loading capacity (57.9 wt%) and a prolonged pH-responsive releasing profile, which is crucial to increase the drug concentration at tumor sites and improve the drug efficacy. Based on these unique features, the nanodrugs significantly inhibit the growth of solid tumors without adverse side effects. Therefore, we anticipate that the arsenic-based nanodrugs generated by this facile synthetic route may be a powerful and alternative strategy for solid tumor therapy.

Graphical abstract: A facile route to core–shell nanoparticulate formation of arsenic trioxide for effective solid tumor treatment

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Publication details

The article was received on 09 Nov 2015, accepted on 22 Jan 2016 and first published on 25 Jan 2016


Article type: Paper
DOI: 10.1039/C5NR07860A
Citation: Nanoscale, 2016,8, 4373-4380
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    A facile route to core–shell nanoparticulate formation of arsenic trioxide for effective solid tumor treatment

    Z. Zhang, H. Liu, H. Zhou, X. Zhu, Z. Zhao, X. Chi, H. Shan and J. Gao, Nanoscale, 2016, 8, 4373
    DOI: 10.1039/C5NR07860A

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