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Issue 2, 2016
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NaYF4:Yb/Er@PPy core–shell nanoplates: an imaging-guided multimodal platform for photothermal therapy of cancers

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Abstract

Imaging guided photothermal agents have attracted great attention for accurate diagnosis and treatment of tumors. Herein, multifunctional NaYF4:Yb/Er@polypyrrole (PPy) core–shell nanoplates are developed by combining a thermal decomposition reaction and a chemical oxidative polymerization reaction. Within such a composite nanomaterial, the core of the NaYF4:Yb/Er nanoplate can serve as an efficient nanoprobe for upconversion luminescence (UCL)/X-ray computed tomography (CT) dual-modal imaging, the shell of the PPy shows strong near infrared (NIR) region absorption and makes it effective in photothermal ablation of cancer cells and infrared thermal imaging in vivo. Thus, this platform can be simultaneously used for cancer diagnosis and photothermal therapy, and compensates for the deficiencies of individual imaging modalities and satisfies the higher requirements on the efficiency and accuracy for diagnosis and therapy of cancer. The results further provide some insight into the exploration of multifunctional nanocomposites in the photothermal theragnosis therapy of cancers.

Graphical abstract: NaYF4:Yb/Er@PPy core–shell nanoplates: an imaging-guided multimodal platform for photothermal therapy of cancers

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Supplementary files

Article information


Submitted
16 Sep 2015
Accepted
25 Nov 2015
First published
14 Dec 2015

Nanoscale, 2016,8, 1040-1048
Article type
Paper

NaYF4:Yb/Er@PPy core–shell nanoplates: an imaging-guided multimodal platform for photothermal therapy of cancers

X. Huang, B. Li, C. Peng, G. Song, Y. Peng, Z. Xiao, X. Liu, J. Yang, L. Yu and J. Hu, Nanoscale, 2016, 8, 1040
DOI: 10.1039/C5NR06394A

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