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Issue 1, 2016
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Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

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Abstract

Targeted imaging and tumor therapy using nanomaterials has stimulated research interest recently, but the high cytotoxicity and low cellular uptake of nanomaterials limit their bioapplication. In this paper, glucose (Glc) was chosen to functionalize Au nanoprisms (NPrs) for improving the cytotoxicity and cellular uptake of Au@PEG-Glc NPrs into cancer cells. Glucose is a primary source of energy at the cellular level and at cellular membranes for cell recognition. A coating of glucose facilitates the accumulation of Au@PEG-Glc NPrs in a tumor region much more than Au@PEG NPrs. Due to the high accumulation and excellent photoabsorbing property of Au@PEG-Glc NPrs, enhanced optoacoustic imaging of a tumor in vivo was achieved, and visualization of the tumor further guided cancer treatment. Based on the optical–thermal conversion performance of Au@PEG-Glc NPrs, the tumor in vivo was effectively cured through photothermal therapy. The current work demonstrates the great potential of Au@PEG-Glc NPrs in optoacoustic imaging and photothermal cancer therapy in future.

Graphical abstract: Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

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Publication details

The article was received on 11 Sep 2015, accepted on 22 Nov 2015 and first published on 03 Dec 2015


Article type: Paper
DOI: 10.1039/C5NR06261F
Citation: Nanoscale, 2016,8, 492-499
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    Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

    J. Han, J. Zhang, M. Yang, D. Cui and J. M. de la Fuente, Nanoscale, 2016, 8, 492
    DOI: 10.1039/C5NR06261F

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