Issue 10, 2016
From the journal:

New Journal of Chemistry

A biocompatible inverse electron demand Diels–Alder reaction of aldehyde and tetrazine promoted by proline†

Shuiqin Lai,a   Wuyu Mao,a   Heng Song,a   Lingying Xiaa  and  Hexin Xie ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: xiehexin@ecust.edu.cn

Abstract

A proline-mediated inverse electron demand Diels–Alder reaction of aldehyde and tetrazine is disclosed. This biocompatible reaction is very fast (with apparent k2 up to 13.8 M−1 s−1) and has been used in the labeling of bovine serum albumin in aqueous medium.

Graphical abstract: A biocompatible inverse electron demand Diels–Alder reaction of aldehyde and tetrazine promoted by proline

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Article information

DOI
https://doi.org/10.1039/C6NJ01567K
Article type
Letter
Submitted
17 May 2016
Accepted
02 Aug 2016
First published
02 Aug 2016

New J. Chem., 2016,40, 8194-8197

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A biocompatible inverse electron demand Diels–Alder reaction of aldehyde and tetrazine promoted by proline

S. Lai, W. Mao, H. Song, L. Xia and H. Xie, New J. Chem., 2016, 40, 8194 DOI: 10.1039/C6NJ01567K

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