Issue 7, 2016
From the journal:

New Journal of Chemistry

A new rosamine-based fluorescent chemodosimeter for hydrogen sulfide and its bioimaging in live cells†

Junye Cheng,‡a   Jianhua Song,‡a   Huawei Niu,a   Jun Tang,a   Di Zhang,*b   Yufen Zhaoac  and  Yong Ye*ac  

* Corresponding authors

a Phosphorus Chemical Engineering Research Center of Henan Province, The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

b Institute of Agricultural Quality Standards and Testing Technology, Henan Academy of Agricultural Sciences, Zhengzhou, China
E-mail: pandy811@163.com

c Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China
E-mail: yeyong03@tsinghua.org.cn

Abstract

A new probe (RosN3), which displayed excellent selectivity to H2S in mixed aqueous media, was synthesized. This method employed the H2S-mediated reduction of azides to amines, resulting in fluorescence quenching. The probe exhibited high H2S selectivity over other common anions and biothiols. The detection limit was measured to be 0.25 μM. Furthermore, the live cell imaging results demonstrated its potential for practical application in biological systems.

Graphical abstract: A new rosamine-based fluorescent chemodosimeter for hydrogen sulfide and its bioimaging in live cells

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Article information

DOI
https://doi.org/10.1039/C6NJ00177G
Article type
Paper
Submitted
18 Jan 2016
Accepted
09 May 2016
First published
10 May 2016

New J. Chem., 2016,40, 6384-6388

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A new rosamine-based fluorescent chemodosimeter for hydrogen sulfide and its bioimaging in live cells

J. Cheng, J. Song, H. Niu, J. Tang, D. Zhang, Y. Zhao and Y. Ye, New J. Chem., 2016, 40, 6384 DOI: 10.1039/C6NJ00177G

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