ZnO nanoparticle–β-cyclodextrin: a recyclable heterogeneous catalyst for the synthesis of 3-aryl-4H-benzo[1,4]thiazin-2-amine in water

Abstract

A combination of ZnO nanoparticles and β-cyclodextrin was used as an efficient and green catalytic system for the synthesis of 3-aryl-4H-benzo[1,4]thiazin-2-amine via a one-pot, three-component reaction of an o-amino thiophenol, aromatic aldehydes and isocyanides in good to excellent yields at 60 °C in water. The nano size of ZnO was confirmed by transmission electron microscopy (TEM), XRD and UV-visible spectral techniques. A high catalytic activity and easy recovery and reuse for several cycles with consistent activity are additional eco-friendly attributes of this catalytic system.