The evaluation of lanthanum trapped prussian blue as a phosphate binding agent with reduced bone uptake

Abstract

Toxicity arising from lanthanum accumulation in bone and liver is a big concern in the usage of lanthanum carbonate as a phosphate binder. In this paper colloidal lanthanum trapped Prussian blue is developed as a two-process-independent phosphate binder, which meets the requirement of separating two processes. The layered nanostructure of the as-formed LaPO₄–PB hints its high binding affinity of phosphate and stability of lanthanum, hence free from absorption through the gastrointestinal tract, thus reducing lanthanum accumulation in the bone and liver is evidenced after long-term administration. Those results indicate that lanthanum trapped Prussian blue is a safe phosphate binder alternative to lanthanum carbonate.