Homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H) as an efficient catalyst for one-pot synthesis of 1-amidoalkyl-2-naphthols

Abstract

Mesoporous silica nanoparticles are efficiently functionalized with homopiperazine sulfamic acid. The resulting MSNs-HPZ-SO₃H is employed as a nanocatalyst in one-pot synthesis of 1-amidoalkyl-2-naphthols, through three-component condensation reaction of aromatic aldehydes, amides/urea and β-naphthol, under thermal solvent-free conditions. Characterizations of the catalyst are carried out using XRD, SEM, FT-IR, TGA-DTA and nitrogen adsorption–desorption analysis. This protocol is developed as a safe and convenient alternative method for the synthesis of 1-amidoalkyl-2-naphthols utilizing an ecofriendly catalyst.