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Issue 2, 2016
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In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

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Abstract

This work reports the synthesis and characterization of palladium(II) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthaldehyde thiosemicarbazone; L2H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L3H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L4H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L1)2 has the most potent activity for all the studied cell lines (IC50 ∼ 1 μM), with the exception of H460. Pd(L2)2 is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L4)2 is the complex which exhibits the lowest activity against the same cell line (IC50 ∼ 11 μM), being ten times lower than that of Pd(L1)2. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11–13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L1)2, Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145, while those with Pd(L2)2, Pd(L3)2 and Pd(L4)2 against HuTu80.

Graphical abstract: In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

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The article was received on 10 Sep 2015, accepted on 08 Dec 2015 and first published on 11 Dec 2015


Article type: Paper
DOI: 10.1039/C5NJ02429C
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Citation: New J. Chem., 2016,40, 1853-1860
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    In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

    W. Hernández, Abraham. J. Vaisberg, M. Tobar, M. Álvarez, J. Manzur, Y. Echevarría and E. Spodine, New J. Chem., 2016, 40, 1853
    DOI: 10.1039/C5NJ02429C

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