Issue 3, 2016

A convenient and rapid microwave-assisted synthesis of spirooxindoles in aqueous medium and their antimicrobial activities

Abstract

A simple, ecofriendly and one-pot three-component aqueous phase protocol is developed for the synthesis of functionalized spirooxindole derivatives by the reaction of isatin, β-nitrostyrene and benzyl amine/α-amino acids in water under microwave irradiation. The method allows the easy construction of a library of spirooxindoles in moderate to good yields with good diastereoselectivity starting from readily available precursors. In addition, all the synthesized compounds were screened for antimicrobial activity and the majority of compounds showed significant activity against Escherichia coli ATCC 10536, Candida tropicalis ATCC 750, Staphylococcus aureus ATCC25923 and Pseudomonas aeruginosa ATCC 15442.

Graphical abstract: A convenient and rapid microwave-assisted synthesis of spirooxindoles in aqueous medium and their antimicrobial activities

Supplementary files

Article information

Article type
Paper
Submitted
10 Aug 2015
Accepted
15 Dec 2015
First published
16 Dec 2015

New J. Chem., 2016,40, 2225-2232

A convenient and rapid microwave-assisted synthesis of spirooxindoles in aqueous medium and their antimicrobial activities

P. R. Mali, L. Chandrasekhara Rao, V. M. Bangade, P. K. Shirsat, S. A. George, N. Jagadeesh babu and H. M. Meshram, New J. Chem., 2016, 40, 2225 DOI: 10.1039/C5NJ02126J

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