Issue 1, 2016

Efficient solid phase extraction of codeine from human urine samples using a novel magnetic molecularly imprinted nanoadsorbent and its spectrofluorometric determination

Abstract

From a medical or clinical point of view, to assess toxicity, adverse effects, interactions and therapeutic efficiency, monitoring drug levels in body fluids, such as urine and plasma, has become increasingly necessary. This study reports on a novel method for determination of trace concentration levels of codeine phosphate in human urine samples. In this regard, a solid phase extraction step, based on a novel magnetic molecularly imprinted polymer nanoadsorbent, has been developed to be used prior to spectrofluorometric analysis of the drug. After optimization of various factors, such as pH, contact time, adsorbent dosage and desorbing solvent, the results showed that using the proposed method sensitive and accurate determination of the drug in the concentration range of 2.0–500.0 ng mL−1 with the detection limit of 0.67 ng mL−1 is achievable. The urine sample analysis results show that a powerful method for codeine phosphate determination has been proposed.

Graphical abstract: Efficient solid phase extraction of codeine from human urine samples using a novel magnetic molecularly imprinted nanoadsorbent and its spectrofluorometric determination

Article information

Article type
Paper
Submitted
22 Jun 2015
Accepted
06 Oct 2015
First published
12 Oct 2015

New J. Chem., 2016,40, 122-129

Author version available

Efficient solid phase extraction of codeine from human urine samples using a novel magnetic molecularly imprinted nanoadsorbent and its spectrofluorometric determination

T. Madrakian, F. Fazl, M. Ahmadi and A. Afkhami, New J. Chem., 2016, 40, 122 DOI: 10.1039/C5NJ01588J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements