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Issue 5, 2016
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Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration

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Abstract

Deep eutectic solvents (DESs) are a new class of green solvents used to dissolve non-steroidal anti-inflammatory drugs (NSAIDs) for potential non-aqueous liquid administration applications. Several NSAIDs are readily soluble in various DESs to a high concentration. Aspirin, a hydrolabile NSAID, was 8.2-fold more stable against cleavage in DES than in water.

Graphical abstract: Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration

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Publication details

The article was received on 29 Nov 2015, accepted on 26 Feb 2016 and first published on 29 Feb 2016


Article type: Research Article
DOI: 10.1039/C5MD00551E
Med. Chem. Commun., 2016,7, 955-959

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    Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration

    C. Lu, J. Cao, N. Wang and E. Su, Med. Chem. Commun., 2016, 7, 955
    DOI: 10.1039/C5MD00551E

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