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Issue 3, 2016
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Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action

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Abstract

A series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines. Among the studied compounds, squaramide 34 showed a potent and selective cytotoxicity against the human gastric cancer cell line HGC-27. Studies directed to elucidate the mechanism of induced cell death were performed. Cell cycle distribution analysis and cell death studies showed that compound 34 induces cell cycle arrest at the G1 phase and caspase-dependent apoptosis. In conclusion, squaramide 34 can be considered a potential anticancer agent for gastric carcinoma.

Graphical abstract: Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action

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Publication details

The article was received on 06 Nov 2015, accepted on 22 Feb 2016 and first published on 09 Mar 2016


Article type: Research Article
DOI: 10.1039/C5MD00515A
Med. Chem. Commun., 2016,7, 550-561
  • Open access: Creative Commons BY license
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    Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action

    M. Quintana, J. V. Alegre-Requena, E. Marqués-López, R. P. Herrera and G. Triola, Med. Chem. Commun., 2016, 7, 550
    DOI: 10.1039/C5MD00515A

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