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Issue 1, 2016
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Molecular basis for resistance against phosphonate antibiotics and herbicides

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Abstract

Research studies in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review the current state of knowledge of the structural and biochemical characterization of resistance mechanisms against these bioactive natural products. Advances in the understanding of these resistance determinants have spurred knowledge-based campaigns aimed at the design of derivatives that retain biological activity but are less prone to tolerance.

Graphical abstract: Molecular basis for resistance against phosphonate antibiotics and herbicides

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Publication details

The article was received on 18 Aug 2015, accepted on 07 Oct 2015 and first published on 12 Oct 2015


Article type: Review Article
DOI: 10.1039/C5MD00351B
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Med. Chem. Commun., 2016,7, 28-36

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    Molecular basis for resistance against phosphonate antibiotics and herbicides

    J. R. Chekan, D. P. Cogan and S. K. Nair, Med. Chem. Commun., 2016, 7, 28
    DOI: 10.1039/C5MD00351B

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