Issue 10, 2016
From the journal:

Molecular BioSystems

Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells†

Jia Zhao,a   Quyen Vua  and  Cliff I. Stains*a  

* Corresponding authors

a Department of Chemistry, University of Nebraska – Lincoln, Lincoln, NE 68588, USA
E-mail: cstains2@unl.edu

Abstract

Luminescent, cell-based assays capable of monitoring the aggregation potential of the disease-relevant proteins known as amylin (type 2 diabetes) and huntingtin (Huntington's disease) are presented. These sensitive platforms report on the influence of mutations as well as small molecules on protein solubility.

Graphical abstract: Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells

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Article information

DOI
https://doi.org/10.1039/C6MB00454G
Article type
Communication
Submitted
08 Jun 2016
Accepted
28 Jul 2016
First published
28 Jul 2016

Mol. BioSyst., 2016,12, 2984-2987

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Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells

J. Zhao, Q. Vu and C. I. Stains, Mol. BioSyst., 2016, 12, 2984 DOI: 10.1039/C6MB00454G

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