Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications

G. Laffite; C. Leroy; C. Bonhomme; L. Bonhomme-Coury; E. Letavernier; M. Daudon; V. Frochot; J. P. Haymann; S. Rouzière; I. T. Lucas; D. Bazin; F. Babonneau; A. Abou-Hassan

doi:10.1039/C6LC00197A

Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications†

G. Laffite,^ab C. Leroy,^b C. Bonhomme,^b L. Bonhomme-Coury,^b E. Letavernier,^c M. Daudon,^c V. Frochot,^c J. P. Haymann,^c S. Rouzière,^d I. T. Lucas,^e D. Bazin,^bd F. Babonneau^b and A. Abou-Hassan*^a

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^a Sorbonne Universités, UPMC Univ Paris 06, UMR 8234 CNRS, Laboratoire Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux (PHENIX), 4 place Jussieu - case 51, Paris, France
E-mail: ali.abou_hassan@upmc.fr

^b Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, Paris, France

^c Sorbonne Universités, UPMC Univ Paris 06, AP-HP, INSERM, Service d'Explorations Fonctionnelles, Hôpital Tenon, 4 rue de la Chine, Paris, France

^d Laboratoire de Physique des Solides, CNRS UMR 8502, Université Paris-Sud, Bât 510, Orsay, France

^e Sorbonne Universités, UPMC Univ Paris 06, UMR 8235 CNRS, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), 4 place Jussieu – case 133, Paris, France

Abstract

The effect of mixing calcium and oxalate precursors by diffusion at miscible liquid interfaces on calcium oxalate crystalline phases, and in physiological conditions (concentrations and flow rates), is studied using a microfluidic channel. This channel has similar dimensions as the collection duct in human kidneys and serves as a biomimetic model in order to understand the formation of pathological microcalcifications.

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Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications†

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Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications

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