Enzymatic photosynthesis of formate from carbon dioxide coupled with highly efficient photoelectrochemical regeneration of nicotinamide cofactors

Abstract

We present the photoelectrochemical (PEC) regeneration of nicotinamide cofactors (NADH) coupled with the enzymatic synthesis of formate from CO₂ towards mimicking natural photosynthesis. The water oxidation-driven PEC platform exhibited high yield and the rate of NADH regeneration was compared to many other homogeneous, photochemical systems. We successfully coupled solar-assisted NADH reduction with enzymatic CO₂ reduction to formate under continuous CO₂ injection.