Issue 12, 2016

Heterogeneous catalytic approaches in C–H activation reactions


Despite the undisputed advances and progress in metal-catalyzed C–H functionalizations, this atom-economical approach had thus far largely been developed with the aid of various metal catalysts that were operative in a homogeneous fashion. While thereby major progress was accomplished, these catalytic systems featured notable disadvantages, such as low catalyst recyclability. This review summarizes the development of user-friendly, recyclable and easily separable heterogeneous catalysts for C–H activation. This strategy was characterized by a remarkably broad substrate scope, considerable levels of chemo- and site-selectivities and proved applicable to C–C as well as C–heteroatom formation processes. Thus, recyclable catalysts were established for arylations, hydroarylations, alkenylations, acylations, nitrogenations, oxygenations, or halogenations, among others. The rapid recent progress in selective heterogeneous C–H functionalizations during the last decade until December 2015 is reviewed.

Graphical abstract: Heterogeneous catalytic approaches in C–H activation reactions

Article information

Article type
Critical Review
09 Feb 2016
10 Mar 2016
First published
10 Mar 2016
This article is Open Access
Creative Commons BY license

Green Chem., 2016,18, 3471-3493

Heterogeneous catalytic approaches in C–H activation reactions

S. Santoro, S. I. Kozhushkov, L. Ackermann and L. Vaccaro, Green Chem., 2016, 18, 3471 DOI: 10.1039/C6GC00385K

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