Metal-free cascade oxidative decarbonylative alkylarylation of acrylamides with aliphatic aldehydes: a convenient approach to oxindoles via dual C(sp2)–H bond functionalization

Abstract

A convenient metal-free cascade oxidative decarbonylative alkylarylation of acrylamides with aliphatic aldehydes to provide quaternary oxindoles is developed. With DTBP as an oxidant and radical-initiator, this reaction efficiently converts cheap and abundant aliphatic aldehydes into valuable alkyl radicals for the cascade construction of C(sp³)–C(sp³) and C(sp³)–C(sp²) bonds via dual C(sp²)–H bond functionalization.