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Issue 44, 2016
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Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes

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Diagnosis by MRI is frequently non-trivial due to the low sensitivity of the technique. Signal enhancing contrast agents (CAs) are used to aid in the analysis of MR images. We present here a simple protocol for the preparation of responsive CAs based on Mn nanosheets. Mn nanostructures presented here undergo a chemical and structural change in the presence of altered physiological conditions that activate their signal. This strategy allows for a reduction of background, increasing the sensitivity of the technique. The simple synthetic protocol followed allows for the combination of the nanosheets with reporter molecules for other imaging techniques, like carbon quantum dots for optical imaging.

Graphical abstract: Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes

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Supplementary files

Article information

18 Jul 2016
05 Oct 2016
First published
06 Oct 2016

Dalton Trans., 2016,45, 17672-17680
Article type

Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes

J. Gallo, N. Vasimalai, M. T. Fernandez-Arguelles and M. Bañobre-López, Dalton Trans., 2016, 45, 17672
DOI: 10.1039/C6DT02840C

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