A Ru(II) arene complex with a NO-releasing 4-nitrooxymethyl-pyridine ligand shows increased cytotoxicity against the non-small cell lung cancer cell line A549 as compared to either the free ligand or the unfunctionalized complex. EPR spin-trapping studies show that NO release is selective, being limited in phosphate buffered saline or human serum, but promoted by glutathione.
J. Zhao, K. E. Prosser, S. W. Chang, S. P. Zakharia and C. J. Walsby, Dalton Trans., 2016, 45, 18079 DOI: 10.1039/C6DT03661A
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