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Issue 33, 2016
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A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action

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Abstract

A rhodium(I) and a ruthenium(II) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(II) complex was largely inactive, the rhodium(I) NHC complex displayed selective cytotoxicity and significant anti-metastatic and in vivo anti-vascular activities and acted as both a mammalian and an E. coli thioredoxin reductase inhibitor. In HCT-116 cells it increased the reactive oxygen species level, leading to DNA damage, and it induced cell cycle arrest, decreased the mitochondrial membrane potential, and triggered apoptosis. This rhodium(I) NHC derivative thus represents a multi-target compound with promising anti-cancer potential.

Graphical abstract: A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action

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Supplementary files

Article information


Submitted
20 May 2016
Accepted
07 Jun 2016
First published
08 Jun 2016

This article is Open Access

Dalton Trans., 2016,45, 13161-13168
Article type
Paper

A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex: evaluation of the mechanism of action

J. Zhang, J. K. Muenzner, M. A. Abu el Maaty, B. Karge, R. Schobert, S. Wölfl and I. Ott, Dalton Trans., 2016, 45, 13161
DOI: 10.1039/C6DT02025A

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