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Issue 32, 2016
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Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

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Abstract

Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.

Graphical abstract: Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

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Publication details

The article was received on 17 May 2016, accepted on 23 May 2016 and first published on 24 May 2016


Article type: Communication
DOI: 10.1039/C6DT01979J
Citation: Dalton Trans., 2016,45, 12627-12631
  • Open access: Creative Commons BY-NC license
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    Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

    C. Cheignon, F. Collin, P. Faller and C. Hureau, Dalton Trans., 2016, 45, 12627
    DOI: 10.1039/C6DT01979J

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