A highly enantioselective Mannich reaction between 3-substituted-2H-1,4-benzoxazines and acetone catalyzed by lipase from wheat germ type I (WGL) is described. Enantioselectivity of up to 95% ee was achieved in DMSO at 25 °C. This research provides a new and simple method for the synthesis of β-amino ketone derivatives and promotes the development of enzyme-catalyzed Mannich reactions.
L. Wu, Y. Xiang, D. Yang, Z. Guan and Y. He, Catal. Sci. Technol., 2016, 6, 3963 DOI: 10.1039/C5CY01923K
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