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Issue 11, 2016
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New amination strategies based on nitrogen-centered radical chemistry

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Abstract

The interesting and diverse biological activities of nitrogen-containing compounds make the construction of the C–N bond of great importance. Despite the tremendous advances that have been made in this research field, C–N bond formation based on nitrogen-centered radicals remains a significant challenge due to the harsh conditions required for the generation of nitrogen-centered radicals and their propensity for hydrogen abstraction or engaging in other degradation pathways. In the past several years, novel methodologies for C–N bond constructions based on nitrogen centered-radical intermediates, coordinated with metal or generated in the presence of visible-light and a photocatalyst, have attracted considerable attention. This tutorial review will summarize the significant progress of these efficient and mild radical amination reactions, with an emphasis on approaches for the generation of nitrogen-centered radicals and their reaction patterns, related mechanisms and synthetic applications, as well as unmet challenges in this emerging and promising field.

Graphical abstract: New amination strategies based on nitrogen-centered radical chemistry

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Publication details

The article was received on 12 Nov 2015 and first published on 27 Apr 2016


Article type: Tutorial Review
DOI: 10.1039/C5CS00852B
Citation: Chem. Soc. Rev., 2016,45, 3069-3087

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    New amination strategies based on nitrogen-centered radical chemistry

    T. Xiong and Q. Zhang, Chem. Soc. Rev., 2016, 45, 3069
    DOI: 10.1039/C5CS00852B

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