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Issue 8, 2016
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Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

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Abstract

The employment of continuous-flow platforms for synthetic chemistry is becoming increasingly popular in research and industrial environments. Integrating analytics in-line enables obtaining a large amount of information in real-time about the reaction progress, catalytic activity and stability, etc. Furthermore, it is possible to influence the reaction progress and selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approach employing digital synthesis. This contribution gives an overview of the most significant contributions in the field to date.

Graphical abstract: Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

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Publication details

The article was received on 21 Oct 2015 and first published on 27 Jan 2016


Article type: Tutorial Review
DOI: 10.1039/C5CS00793C
Citation: Chem. Soc. Rev., 2016,45, 2032-2043

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    Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

    V. Sans and L. Cronin, Chem. Soc. Rev., 2016, 45, 2032
    DOI: 10.1039/C5CS00793C

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