Issue 5, 2016

Smart fluorescent probes for imaging macrophage activity

Abstract

Macrophages are multi-functional immune cells with key roles in host defense and tissue remodelling. The broad array of macrophage functions has prompted the development of very diverse smart fluorescent architectures, rationally designed to elicit a fluorescent signal only after target engagement. This tutorial review covers recent advances in the design, synthesis and application of smart fluorescent probes for imaging macrophage cellular activity, ranging from small fluorophores to peptide-based probes with internally quenched fluorescent pairs or activity-based reactive groups.

Graphical abstract: Smart fluorescent probes for imaging macrophage activity

Supplementary files

Article information

Article type
Tutorial Review
Submitted
18 Jul 2015
First published
11 Jan 2016
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2016,45, 1182-1196

Author version available

Smart fluorescent probes for imaging macrophage activity

A. Fernández and M. Vendrell, Chem. Soc. Rev., 2016, 45, 1182 DOI: 10.1039/C5CS00567A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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