Issue 6, 2016

Cascade polycyclizations in natural product synthesis


Cascade (domino) reactions have an unparalleled ability to generate molecular complexity from relatively simple starting materials; these transformations are particularly appealing when multiple rings are forged during this process. In this tutorial review, we cover recent highlights in cascade polycyclizations as applied to natural product synthesis, including pericyclic, heteroatom-mediated, cationic, metal-catalyzed, organocatalytic, and radical sequences.

Graphical abstract: Cascade polycyclizations in natural product synthesis

Article information

Article type
Tutorial Review
03 Feb 2015
First published
21 Jan 2016
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2016,45, 1557-1569

Author version available

Cascade polycyclizations in natural product synthesis

R. Ardkhean, D. F. J. Caputo, S. M. Morrow, H. Shi, Y. Xiong and E. A. Anderson, Chem. Soc. Rev., 2016, 45, 1557 DOI: 10.1039/C5CS00105F

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