Jump to main content
Jump to site search

Issue 22, 2016
Previous Article Next Article

Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

Author affiliations

Abstract

The phase behavior of a mixture of a typical insect pheromone (olean) and a phospholipid (DOPC)/water dispersion is extensively explored through SAXS, NMR and DSC experiments. The results mimic those obtained with anaesthetics in phospholipid/water systems. They also mimic the behavior and microstructure of ternary mixtures of a membrane mimetic, bilayer-forming double chained surfactants, oils and water. Taken together with recent models for conduction of the nervous impulse, all hint at lipid involvement and the underlying unity in mechanisms of pheromone, anaesthetic and hydrophobic drugs, where a local phase change in the lipid membrane architecture may be at least partly involved in the transmission of the signal.

Graphical abstract: Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Jan 2016, accepted on 06 May 2016 and first published on 06 May 2016


Article type: Paper
DOI: 10.1039/C6CP00659K
Author version
available:
Download author version (PDF)
Citation: Phys. Chem. Chem. Phys., 2016,18, 15375-15383
  •   Request permissions

    Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

    S. Borsacchi, M. Geppi, S. Macchi, B. W. Ninham, E. Fratini, M. Ambrosi, P. Baglioni and P. Lo Nostro, Phys. Chem. Chem. Phys., 2016, 18, 15375
    DOI: 10.1039/C6CP00659K

Search articles by author

Spotlight

Advertisements