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Issue 26, 2016
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Host–guest complexes of cucurbit[6]uril with the trypanocide drug diminazene and its degradation product 4-aminobenzamidine

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Abstract

Here, we describe the cocrystallization of the trypanocide drug diminazene with the macrocyclic host cucurbit[6]uril (CB6). When the acid-contaminated CB6 was used, diminazene and the product of its hydrolysis cocrystallized with CB6. The use of an acid-free macrocycle afforded a host–guest complex where diminazene guest molecules are complexed exo to the host cavity.

Graphical abstract: Host–guest complexes of cucurbit[6]uril with the trypanocide drug diminazene and its degradation product 4-aminobenzamidine

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Article information


Submitted
31 Jan 2016
Accepted
08 Apr 2016
First published
11 Apr 2016

This article is Open Access

CrystEngComm, 2016,18, 4905-4908
Article type
Communication

Host–guest complexes of cucurbit[6]uril with the trypanocide drug diminazene and its degradation product 4-aminobenzamidine

O. Danylyuk, H. Butkiewicz and V. Sashuk, CrystEngComm, 2016, 18, 4905
DOI: 10.1039/C6CE00257A

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